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. 2020 Oct 13;104(2):445–456. doi: 10.1093/biolre/ioaa192

Figure 2.

Figure 2

PGRMC expression during early and late preterm labor. (A) Immunohistochemistry localized PGRMC1 and PGRMC2 in fetal membrane tissues from preterm birth (PTB) and preterm premature rupture of membrane (pPROM) (×40); Scale bar = 30 μm. (B) Western blot analysis of PGRMC1 and PGRMC2 in full fetal membranes from early, <34 weeks gestational age (WGA), and late, >34 WGA; preterm birth deliveries were collected for analysis. (C) Densitometry showed PGRMC2 significantly decreased in pPROM membranes compared with PTB (P = 0.01), whereas the PGRMC1 level did not change. When divided into early and late phenotypes, early pPROM had significantly less PGRMC1 (P = 0.02) and PGRMC2 (P = 0.009) compared with early PTB. In addition, early PTB also expressed significantly higher PGRMC2 than late pPROM (P = 0.04) (N = 5; mean ± SEM). Scale bar is 50 μm.