Table 1.

The Expression Redox State of Trx in AD Models and Patients.

Subjects	Expression and redox status of Trx	References
AD patients	↑Trx-1 in cerebrospinal fluid	Arodin et al., 2014
	↑Trx-1 in the plasma	Arodin et al., 2014; Cornelius et al., 2013
	↓Trx-1 in the brain	Di Domenico et al., 2010
	↓Trx-1 in the frontal cortex and hippocampal CA1 regions	Akterin et al., 2006
	↓Trx-2 in hippocampus tissues	Arodin et al., 2014
APP/PS1 mice	↓Synaptic Trx	Kommaddi et al., 2019
Mice expressing ApoE4, SH-SY5Y/human primary cortical neurons treated with recombinant ApoE4	↓Trx-1	Persson et al., 2017
Aβ1-42-treated mice	↓Trx-1 in hippocampal neurons	Duan and Si, 2019
SH-SY5Y cells treated with Aβ1-42	↑Oxidation of Trx-1	Akterin et al.,2006
Primary cerebral cortical neurons and HT22 hippocampal cells from Aβ1-42-treated mice	↑Oxidation of Trx-1	Wang, Xu, et al., 2019

Note:↑, increase; ↓, decrease.