Fig. 7.

ESCO2 promotes aerobic glycolysis of LUAD cells by increasing PKM2 expression and decreasing PKM1 expression. a Protein levels were detected in NCI-H1975 cells with ESCO2 stable silencing. b and c Glucose uptake (b) and lactate production (c) were measured in LUAD cells with ESCO2 stable silencing. d and e After 36-h transfection with hnRNPA1 siRNAs into LUAD cells, the cells were transfected with WT hnRNPA1 and its mutant K277R and K277Q plasmids together with ESCO2 plasmids, and then glucose uptake (d) and lactate production (e) were examined. f The working model of ESCO2 promotes aerobic glycolysis and drives tumorigenesis by acetylating hnRNPA1