Table 2.

Rate ratios for relationships between WMS-R LM IIA—Delayed Recall score and ACE-I vs. ARB use over time (n = 1689)

	Overall			APOE ε4 non-carriers			APOE ε4 carriers
	RR [95% CI]	z	p value	RR [95% CI]	z	p value	RR [95% CI]	z	p value
ARBs vs. ACE-Is	1.094 [1.007, 1.188]	2.14	0.0327	1.200 [1.064, 1.354]	2.97	0.0030	1.003 [0.897, 1.122]	0.06	0.9568
C-ARBs vs. NC-ACE-Is	1.250 [1.089, 1.434]	3.16	0.0015	1.354 [1.116, 1.642]	3.08	0.0020	1.130 [0.932, 1.371]	1.25	0.2124
C-ACE-Is vs. NC-ACE-Is	1.158 [1.036, 1.293]	2.57	0.0098	1.168 [0.995, 1.385]	1.90	0.0571	1.140 [0.976, 1.331]	1.65	0.0993
NC-ARBs vs. NC-ACE-Is	1.199 [1.055, 1.365]	2.79	0.0054	1.324 [1.108, 1.583]	3.07	0.0021	1.104 [0.923, 1.321]	1.08	0.2785
C-ARBs vs. NC-ARBs	1.042 [0.921, 1.179]	0.65	0.5175	1.022 [0.865, 1.208]	0.26	0.7947	1.024 [0.869, 1.205]	0.28	0.7802
C-ARBs vs. C-ACE-Is	1.080 [0.965, 1.209]	1.34	0.1798	1.159 [0.985, 1.364]	1.78	0.0746	0.992 [0.854, 1.152]	− 0.11	0.9161

Three-way APOE × ARB vs. ACE-I × Time interaction: RR = 1.196 [1.015, 1.410], z = 2.135, p = 0.0328

C-ARB: BBB-crossing ARB; C-ACE-I: BBB-crossing ACE-I; NC-ARB: Non-BBB-crossing ARB; NC-ACE-I: Non-BBB-crossing ACE-I