Table 4.
Univariate and multivariate Cox regression analyses of various prognostic parameters of relapse-free survival in patients with breast cancer.
| Parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| ER (negative vs. positive) | 1.643 (1.062-2.542) | 0.026 | 1.340 (0.611-2.937) | 0.465 |
| PR (negative vs. positive) | 1.641 (1.088-2.477) | 0.018 | 1.402 (0.657-2.994) | 0.383 |
| T classification | ||||
| T2 vs. T1 | 1.635 (0.944-2.833) | 0.079 | 1.235 (0.631-2.417) | 0.537 |
| T3 vs. T1 | 2.524 (1.321-4.824) | 0.005 | 1.267 (0.487-3.299) | 0.628 |
| T4 vs. T1 | 6.72 (2.885-15.656) | <0.001 | 2.013 (0.553-7.321) | 0.288 |
| N classification | ||||
| N1 vs. N0 | 2.255 (1.357-3.748) | 0.002 | 1.560 (0.822-2.958) | 0.173 |
| N2 vs. N0 | 2.642 (1.326-5.264) | 0.006 | 2.741 (0.749-10.035) | 0.128 |
| N3 vs. N0 | 6.54 (3.415-12.524) | <0.001 | 7.106 (1.998-25.278) | 0.002 |
| M classification (M1 vs. M0) | 4.024 (1.742-9.292) | 0.001 | 1.294 (0.442-3.784) | 0.638 |
| TNM stage (III-IV vs. I-II) | 3.190 (2.106-4.831) | <0.001 | 1.147 (0.375-3.508) | 0.809 |
| Margin status | ||||
| Close vs. negative | 2.228 (0.966-5.141) | 0.060 | 3.229 (1.319-7.905) | 0.010 |
| Positive vs. negative | 2.453 (1.441-4.177) | 0.001 | 1.738 (0.836-3.611) | 0.139 |
| ZNF385B (low vs. high) | 2.227 (1.480-3.349) | <0.001 | 2.609 (1.531-4.449) | <0.001 |
CI: confidence interval; ER: estrogen receptor; HR: hazard ratio; M: metastasis; N: node; PR: progesterone receptor; T: tumor.