Table 1. Comparison of the Cu Level in Tumors, Liver, and Spleen at 24 h Post iv Injection of Cu-LDH Nanoparticles Formulated with Charge-Convertible (PAMA/DMMA and PEG-PA/DM) and Noncharge Convertible (BSA) Polymers.
| surface | LDH | tumor | liver | spleen | |
|---|---|---|---|---|---|
| charge-convertible polymer | Cu-LDH @PAMA/DMMA | % ID | 4.8 | ||
| % ID/g | 37 | 48 (0.77)a | 40 (0.92)a | ||
| Cu-LDH @PEG-PA/DM (Liu et al.32) | % ID/g | 6.0 | |||
| % ID/g | 47 | 48 (0.98) | 45 (1.04) | ||
| BSA | Cu-LDH@BSA (Liu et al.32) | % ID | 3.0 | ||
| % ID/g | 15 | 59 (0.25) | 85 (0.18) | ||
| Cu-LDH@BSA (Li et al.30) | % ID | 3.6 | |||
| % ID/g | 6.4 | 47 (0.14) | 15 (0.43) | ||
| Cu-LDH@BSA (Shi et al.33) | % ID | ||||
| % ID/g | 6.8 | 24 (0.28) | 12 (0.57) | ||
| others | Cy5.5-IPA/LDH (Gao et al.34) | % ID | |||
| % ID/g | 24 | 15 (1.60) | 2 (12.00) | ||
| 5-FU/LDH (Choi et al.35) | % ID | ||||
| % ID/g | 33 | 12 (2.75) | 8 (4.12) | ||
| LDH@PLGA (Ray et al.20) | % ID | ||||
| % ID/g | 20.7 | 16.4 (1.26) | 20.7 (1.00) | ||
a
The value in the parentheses is the ratio of % ID/g in tumor to that in the liver or spleen.