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. Author manuscript; available in PMC: 2021 Feb 11.
Published in final edited form as: Nat Genet. 2020 Nov 23;52(12):1333–1345. doi: 10.1038/s41588-020-00738-2

Fig. 2 |. Stage-specific MTFs are enriched in SMAD1+GATA co-bound regions.

Fig. 2 |

a, Relative enrichment of PU.1 and KLF1 binding at GATA2/1+SMAD1 versus GATA2/1-only sites at D0 and D5. Two-sided Fisher’s exact test used. b, Representative gene tracks at FLI1 and ALAS2 at D0 and D5 showing occupancy of indicated transcription factors relative to ATAC-seq and H3K27ac signal. c, Binding intensities (mean reads per million per bin) of PU.1 and SMAD1 are shown, comparing control and PU.1 overexpressing cells. d. Representative gene tracks at CXCR4 and CXCL2 with peak intensities of PU.1 and SMAD1 in PU.1 over-expressing versus control cells. e, Binding intensities (average reads per bin) of PU.1, SMAD1 and GATA2 are shown, comparing control and PU.1 knockdown cells. f. Representative gene tracks at CD84 and WDR92 showing peak intensities of PU.1, SMAD1 and GATA2 in PU.1 knock down cells compared to control cells.