Table 3.

Risk of ADE after filling a prescription for potentially inappropriate medication (described by ATC code and name of the substance) included in the EU(7)-PIM or AT-PIM list as compared to the control group described as relative risk and risk difference with 95% confidence intervals (CI), uncorrected p-values and p-values corrected for multiplicity by controlling the false discovery rate

ATC code	Substance name	PIM list	Relative risk (95% CI)	Risk difference (95% CI)	P-value	Corrected p-value
A02BC01	Omeprazole	EU(7)	2.95 (1.3, 6.73)	0.02 (0.01, 0.03)	0.010	0.033
A02BC02	Pantoprazole	EU(7)	3.71 (1.37, 10.05)	0.03 (0.02, 0.03)	0.010	0.033
A02BC03	Lansoprazole	EU(7)	1.87 (1.16, 3.01)	0.01 (0, 0.02)	0.010	0.033
A02BC05	Esomeprazole	EU(7)	3.87 (1.38, 10.85)	0.03 (0.02, 0.04)	0.010	0.033
A03FA01	Metoclopramide	EU(7)	2.44 (1.24, 4.79)	0.02 (0.01, 0.02)	0.010	0.033
C01AA04	Digitoxin	EU(7)	1.89 (1.17, 3.06)	0.01 (0, 0.02)	0.010	0.033
C01AA08	Metildigoxin	EU(7)	0.37 (0.17, 0.79)	−0.01 (−0.01, 0)	0.010	0.033
C02AC06	Rilmenidine	EU(7)	2.35 (1.09, 5.09)	0.01 (0, 0.03)	0.030	0.094
C03DA01	Spironolactone	EU(7)	2.47 (1.24, 4.91)	0.02 (0.01, –0.02)	0.010	0.033
N02AX02	Tramadol	EU(7), AT	2.46 (1.24, –4.89)	0.02 (0.01, 0.02)	0.010	0.033
N03AF01	Carbamazepine	EU(7)	0 (0, NaN)	−0.01 (−0.01, −0.01)	0.010	0.033
N05BA01	Diazepam	EU(7), AT	0.4 (0.2, 0.8)	−0.01 (− 0.01, 0)	0.010	0.033
N05BA04	Oxazepam	EU(7), AT	2.85 (1.11, 7.33)	0.02 (0, 0.04)	0.030	0.094
N06AA09	Amitriptyline	EU(7), AT	0.42 (0.22, 0.81)	–0.01 (−0.01, 0)	0.010	0.033
R03DA04	Theophylline	EU(7), AT	2.32 (1.22, –4.41)	0.01 (0.01, 0.02)	0.010	0.033

ATC code Anatomical Therapeutic Chemical Classification System