Table 4.

Explorative analysis of (un)listed potentially inappropriate medication (described by ATC code and name of the substance) for older adults with chronic kidney disease. For each medication the total number of prescriptions and adverse drug events, a number needed to harm, an uncorrected p-value and a p-value corrected for the multiplicity by controlling the false discovery rate are presented. Of these medication midazolam, ofloxacin and dabigatran etexilate are included in the EU(7)-PIM list

ATC code	Substance name	Prescriptions, n	ADE, n	NNH	P-value	Corrected p-value
N05CD08	Midazolam	2	1	2	< 0.001	0.118
J01XA01	Vancomycin	5	1	5	0.001	0.450
C10AC01	Cholestyramine	65	3	21.7	0.004	0.749
J02AC01	Fluconazole	219	6	36.5	0.007	0.829
N05AL05	Amisulpride	47	2	23.5	0.012	0.892
N06AG02	Moclobemide	17	1	17	0.013	0.897
R05DB05	Pentoxyverine	21	1	21	0.019	0.929
M01AG	Fenamate	24	1	24	0.024	0.943
V03AE03	Lanthanum carbonate	168	4	42	0.028	0.950
D01AC12	Fenticonazole	65	2	32.5	0.028	0.950
J01CF05	Flucloxacillin	27	1	27	0.030	0.954
J01CR04	Sultamicillin	181	4	45.3	0.036	0.961
J01EA01	Trimethoprim	747	12	62.3	0.040	0.965
L01AA01	Cyclophosphamide	32	1	32	0.041	0.966
D01AE22	Naftifine	76	2	38	0.041	0.966
D01AE15	Terbinafine	34	1	34	0.046	0.969
C09DX03	Olmesartan medoxomil, Amlodipine and Hydrochlorothiazide	36	1	36	0.051	0.972
P01AB01	Metronidazole	341	6	56.8	0.057	0.975
C05AX03	Haemorrhoid treatment	40	1	40	0.061	0.977
N02AA59	Codeine	41	1	41	0.064	0.978
J01MA01	Ofloxacin	301	5	60.2	0.083	0.983
B01AE07	Dabigatran etexilate	103	2	51.5	0.085	0.983
G01AX11	Povidone-iodine	50	1	50	0.089	0.984
R03BB01	Ipratropium bromide	110	2	55	0.098	0.985

ATC code Anatomical Therapeutic Chemical Classification System, ADE Adverse drug event, NNH Number needed to harm