Table 2.
Multivariate Cox regression for OS and LCSS
| Characteristics | OS | LCSS | ||||
|---|---|---|---|---|---|---|
| HR | 95.0%CI | p | HR | 95.0%CI | p | |
| Gender | ||||||
| Female | 1 | – | 1 | – | ||
| Male | 1.223 | 0.934–1.601 | 0.143 | 1.091 | 0.793–1.503 | 0.592 |
| Age | ||||||
| ≤ 59 | 1 | – | 1 | – | ||
| 60–69 | 1.830 | 1.223–2.740 | 0.003 | 1.742 | 1.097–2.768 | 0.019 |
| 70–79 | 2.646 | 1.813–3.862 | < 0.001 | 2.312 | 1.493–3.581 | < 0.001 |
| ≥ 80 | 4.121 | 2.555–6.648 | < 0.001 | 3.007 | 1.695–5.336 | < 0.001 |
| Laterality | ||||||
| Only one side | 1 | – | 1 | – | ||
| Bilateral | 0.994 | 0.386–2.562 | 0.991 | 1.074 | 0.408–2.827 | 0.886 |
| Grade | ||||||
| Well differentiated | 1 | – | ||||
| Moderately differentiated | 1.118 | 0.787–1.586 | 0.534 | 1.003 | 0.661–1.522 | 0.989 |
| Poorly differentiated/Undifferentiated | 2.569 | 1.483–4.450 | < 0.001 | 2.793 | 1.531–5.093 | < 0.001 |
| Tstage_8th | ||||||
| T1 | 1 | – | 1 | – | ||
| T2 | 1.214 | 0.828–1.778 | 0.320 | 1.351 | 0.819–2.229 | 0.238 |
| T3 | 1.633 | 1.051–2.538 | 0.029 | 2.063 | 1.193–3.566 | 0.010 |
| T4 | 2.925 | 1.996–4.287 | < 0.001 | 4.298 | 2.671–6.917 | < 0.001 |
| Nstage_8th | ||||||
| N0 | 1 | – | 1 | – | ||
| N1 | 1.756 | 1.044–2.954 | 0.034 | 1.936 | 1.100–3.409 | 0.022 |
| N2/3 | 2.232 | 1.337–3.726 | 0.002 | 2.524 | 1.465–4.348 | < 0.001 |
| Mstage_8th | ||||||
| M0 | 1 | – | 1 | – | ||
| M1 | 2.278 | 1.436–3.612 | < 0.001 | 2.202 | 1.327–3.653 | 0.002 |
| Surgery | ||||||
| No | 1 | – | 1 | – | ||
| Yes | 0.467 | 0.305–0.715 | < 0.001 | 0.452 | 0.277–0.737 | 0.001 |
| Radiation | ||||||
| No | 1 | – | 1 | – | ||
| Yes | 1.991 | 1.149–3.449 | 0.001 | 1.931 | 1.061–3.514 | 0.031 |
| Chemotherapy | ||||||
| No/Unknown | 1 | – | 1 | – | ||
| Yes | 1.492 | 1.062–2.096 | 0.021 | 1.730 | 1.193–2.509 | 0.004 |