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. 2021 Feb 10;16:33. doi: 10.1186/s13014-021-01751-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Radiosensitization in cancer stem-like cells enriched culture by AS1411/GNPs. a Picture of mammospheres obtained by the serum free culture of MCF-7 cells. b Real-time PCR data analysis demonstrating the increased expression of Oct4-a in mammospheres (***p < 0.001). c Gel electrophoreses of PCR products of OCT4-a expression in NT2 (positive control), monolayer (nSP) and mammosphere (SP) of MCF7 cells. d Viability of mammosphere cells treated with GNPs or AS1411/GNPs assessed by MTS assay following 24 h treatment with 12.5 mg/L Au. e Radiosensitization effect of the GNPs and AS1411/GNPs (12.5 mg/L) evaluated by clonogenic assay in cancer stem-like cells exposed to 4 MeV electron beams