Table 1.
Characteristics of studies comparing AF IVT with non-AF IVT
| Study | Study design | Comparison | No. of patients | Mean age, y | Men (%) | Treatment | Hypertension (%) | Diabetes mellitus (%) | Dyslipidemia (%) | Baseline NIHSS | Onset to needle (min) | Mortality, % | SICH, % |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bluhmki 2009 [5] | prospective RCT | AF/non-AF | 53/365 | NR | NR |
rtPA 3–4.5 h |
NR | NR | NR | NR | NR | 22.6/5.5, 90d | 17.0/6.6 |
| Kimura 2009 [6] | prospective | AF/non-AF | 44/41 | 77.2/69.4 | 61.4/70.7 |
rtPA < 3 h |
63.6/51.2 | 18.2/22.0 | 13.6/31.7 | 17.3/12.3 | 148.3/147.6 | 18.2/7.3, 90d | NR |
| Awadh 2010 [24] | retrospective | AF/non-AF | 74/154 | 76/66.4 | 40/59 |
rtPA < 4.5 h |
70/64 | 16.2/7.8 | 19/22 | 14/ 14.5 | 162.7/173.3 | NR | 4.0/4.5 |
| Sanak 2010 [16] | retrospective | AF/non-AF | 66/91 | 68.1/66.5 | 57.6/65.9 |
rtPA < 3 h |
NR | NR | NR | 13.0/10.0 | 146.3/145.5 | 18.2/3.3, 7d | 4.5/0 |
| Zhang 2010 [7] | retrospective | AF/non-AF | 22/31 | 68.3/60.7 | 40.9/74.2 |
rtPA < 4.5 h |
72.7/38.5 | 13.6/6.5 | NR | 12.0/9.1 | 203.7/196.7 | 18.2/9.7, 90d | 18.2/6.5 |
| Seet 2011 [8] | retrospective | AF/non-AF | 76/138 | 78.9 /71.5 | 42.1/53.6 |
rtPA < 3 h |
78.9/75.4 | 10.5/14.5 | 50.0/51.4 | 13 /12 | 138.3/143.5 | 22.4/15.2, 90d | 13.2/5.1 |
| Frank 2012 [9] | retrospective | AF/non-AF | 639/2388 | 74.2 /65.7 | 47.3/58.2 |
rtPA < 3 h |
71.1/61.6 | NR | NR | 15 /13 | NR | 21.8/13.6, 90d | 2.7/1.7 |
| Padjen 2013 [10] | prospective | AF/non-AF | 155/579 | 76 /64 | 41.9/55.6 | rtPA | 80.0/62.3 | 20.0/15.7 | 45.2/45.9 | 14/10 | 148/153 | 21.9/9.0, 90d | 5.8/5.5 |
| Saposnik 2013 [11] | prospective | AF/non-AF | 316/1373 | NR | NR | rtPA | NR | NR | NR | NR | NR | 26.3/14.2, 30d | 9.2/6.4 |
| Sung 2013 [14] | retrospective | AF/non-AF | 72/71 | 68.3/64.6 | 58.3/64.8 |
rtPA < 3 h |
79.2/77.5 | 27.8/39.4 | 51.4/64.8 | 17.7/14.4 | 113/119 | 6.9/12.7, 90d | 8.3/9.8 |
| Al-Khaled 2014 [17] | prospective | AF/non-AF | 387/620 | NR | NR |
rtPA < 4.5 h |
NR | NR | NR | NR | up to 4.5 h | 10.8/6.6, in-hospital | 7.5/4.7 |
| Saarinen 2014 [18] | retrospective | AF/non-AF | 92/179 | 77 /69 | 46/55 |
NR < 3 h |
74/63 | 32/17 | NR | NR | NR | 20/6, 90d | NR |
| Tu 2015 [19] | prospective | AF/non-AF | 28/111 | 76.5/73 | 61/52 |
rtPA 3-6 h |
64/64 | 21/26 | 29/32 | 16/11 | NR | 36/16, 90d | 7.1/4.5 |
| Zhao 2017 [12] | retrospective | AF/non-AF | 30/93 | 69.8/63.5 | 46.7/67.7 |
rtPA < 4.5 h |
73.3/65.6 | 30.0/18.3 | 30.0/39.8 | 12/8 | 227/174 | 13.3/2.2 | 13.3/5.4 |
| Mehrpour 2019 [13] | retrospective | AF/non-AF | 24/94 | NR | NR |
rtPA < 4.5 h |
NR | NR | NR | NR | NR | NR | NR |
| Yang 2019 [15] | retrospective | AF/non-AF | 47/56 | 71.2 /60.4 | 34.0/80.4 |
rtPA 3-9 h |
74.5/64.3 | 19.1/23.2 | NR | 11.5 /9.3 | 322.9/370.4 | 10.6/7.1, 90d | 2.1/3.6 |