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. 2021 Jan 28;12:618209. doi: 10.3389/fmicb.2021.618209

FIGURE 5.

FIGURE 5

Quantification of genotoxic activity of cold atmospheric plasma (CAP)-treated pepper mild mottle virus (PMMoV)-free samples. Influence of 5-min and 3-min CAP-treated PMMoV-free samples on induction of DNA damage in HepG2 cells after 2 h (A) and 24 h (B). Data are expressed as quantile box plots. Edges of the plots represent the 25th and 75th percentiles, with 95% confidence intervals. Solid line through the box is the median. NC, negative control (phosphate buffered saline: growth medium, 1:2); PC, positive control: etoposide (10 μg mL–1) for the 2 h time point, and etoposide (5 μg mL–1) for 24 h time point. DNA damage induction by CAP-treated PMMoV-free samples was compared to the induction by the PMMoV-free NC (untreated PMMoV-free sample in growth medium [1:2]); ****p < 0.0001 (Kruskal–Wallis nonparametric tests and Dunn’s multiple comparison tests).