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. 2021 Feb 15;18(1):120–138. doi: 10.20892/j.issn.2095-3941.2020.0105

Figure 1.

Figure 1

RECQL4 is upregulated in esophageal squamous cell carcinoma (ESCC) and high expression of RECQL4 is correlated with tumorigenesis and metastasis. (A) Immunohistochemical staining of RECQL4 expression in ESCC. Images showing different expression levels and cellular distributions are shown. (a) The absence of RECQL4 staining in ESCC; (b) low levels of RECQL4 in the nuclei of ESCC; (c) intermediate levels of RECQL4 in the nuclei of ESCC; (d) high levels of RECQL4 in the nuclei of ESCC; (e) high levels of RECQL4 in both the cytoplasm and nuclei of ESCC; (f) absence of RECQL4 staining in adjacent non-tumor esophageal tissues. Immunohistochemistry was conducted as described in the Materials and methods. All original images were captured at ×400 magnification; scale bars = 20 μm. (B) Images of immunohistochemistry staining of RECQL4 expression in ESCC cancers and lymph node metastatic carcinoma are shown. All original images were captured at ×400 magnification. Scale bars = 20 μm. (C) A total of 41 pairs of ESCCs and lymph node metastatic carcinomas, and expression levels of RECQL4 were evaluated by immunohistochemistry. (D) Cumulative overall survival curves of 100 ESCC patients with different RECQL4 expressions (high and medium or low). The P values were calculated using the log-rank test. *P < 0.05; **P < 0.01; ***P < 0.005.