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HBXIP knockdown inhibits non-small cell lung cancer development in vivo. (A)–(C) Xenografts of HBXIP knockdown (shHB-3) and control (shGFP) A549 cells in athymic mice. Macroscopic images (A) and weights (B) of tumors dissected from mice on day 27 (N = 5). Tumor volumes (C) were measured every 3 days. (D) Immunohistochemical staining of Ki-67, MEK1, and HBXIP in tumor sections from mice described in (A). The results were analyzed by an unpaired t-test. ***P < 0.001.
