Table 2.
Hazard ratios (95% confidence intervals) for biochemical relapse after prostatectomy for established risk factors and ANO7 expression
| Model |
Analyzable (n) | Scenario 4 |
Scenario 3 |
Scenario 2 |
Scenario 1 |
|---|---|---|---|---|---|
| Variable | 9527 | 11,032 | 11,213 | 7214 | |
| Gleason grade biopsy | 3+4 vs. ≤ 3+3 | 1.8 (1.6–2.0), P < 0.0001 | |||
| 4+3 vs. ≤ 3+3 | 3.0 (2.7–3.4), P < 0.0001 | ||||
| ≥ 4+4 vs. ≤ 3+3 | 3.9 (3.4–4.4), P < 0.0001 | ||||
| cT stage | T2a vs. T1c | 1.3 (1.1–1.4), P < 0.0001 | 1.3 (1.1–1.4), P < 0.0001 | ||
| T2b vs. T1c | 1.9 (1.6–2.1), P < 0.0001 | 1.7 (1.5–1.9), P < 0.0001 | |||
| T2c vs. T1c | 1.9 (1.5–2.4), P < 0.0001 | 1.9 (1.5–2.4), P < 0.0001 | |||
| T3a vs. T1c | 1.3 (1.0–1.7), P = 0.0464 | 1.5 (1.2–2.0), P = 0.0011 | |||
| Preoperative PSA level | 4–10 vs. < 4 | 1.6 (1.3–1.9), P < 0.0001 | 1.4 (1.2–1.7), P < 0.0001 | 1.3 (1.1–1.5), P = 0.0008 | |
| 10–20 vs. < 4 | 2.4 (2.0–2.8), P < 0.0001 | 2.0 (1.7–2.4), P < 0.0001 | 1.7 (1.4–2.0), P < 0.0001 | ||
| > 20 vs. < 4 | 3.8 (3.1–4.6), P < 0.0001 | 2.9 (2.4–3.4), P < 0.0001 | 2.0 (1.7–2.4), P < 0.0001 | ||
| ANO7 expression | Moderate vs. strong | 1.3 (1.2–1.5), P < 0.0001 | 1.2 (1.1–1.3), P = 0.000 | 1.1 (1.0–1.2), P = 0.0373 | 1.1 (1.0–1.2), P = 0.0645 |
| Weak vs. strong | 1.8 (1.6–2.1), P < 0.0001 | 1.5 (1.3–1.8), P < 0.0001 | 1.3 (1.1–1.5), P = 0.0003 | 1.3 (1.4–1.6), P = 0.0003 | |
| Negative vs. strong | 2.0 (1.7–2.3), P < 0.0001 | 1.6 (1.4–1.9), P < 0.0001 | 1.5 (1.3–1.7), P < 0.0001 | 1.4 (1.2–1.7), P < 0.0001 | |
| Gleason grade prostatectomy | 3+4 vs. ≤ 3+3 | 2.9 (2.5–3.3), P < 0.0001 | 2.3 (2.0–2.7), P < 0.0001 | 2.1 (1.7–2.7), P < 0.0001 | |
| 4+3 vs. ≤ 3+3 | 7.3 (6.2–8.6), P < 0.0001 | 4.9 (4.1–5.8), P < 0.0001 | 4.3 (3.4–5.4), P < 0.0001 | ||
| 3+4 Tert. 5 vs. ≤ 3+3 | 5.2 (4.1–6.6), P < 0.0001 | 3.5 (2.8–4.4), P < 0.0001 | 3.2 (2.4–4.2), P < 0.0001 | ||
| 4+3 Tert. 5 vs. ≤ 3+3 | 11.3 (9.4–13.5), P < 0.0001 | 6.1 (5.1–7.4), P < 0.0001 | 5.1 (4.0–6.5), P < 0.0001 | ||
| ≥ 4+4 vs. ≤ 3+3 | 14.0 (11.7–16.9), P < 0.0001 | 6.8 (5.6–8.3), P < 0.0001 | 5.5 (4.3–7.1), P < 0.0001 | ||
| pT stage | T3a vs. T2 | 2.0 (1.8–2.2), P < 0.0001 | 2.0 (1.8–2.2), P < 0.0001 | ||
| T3b-4 vs. T2 | 3.3 (2.9–3.7), P < 0.0001 | 2.9 (2.5–3.3), P < 0.0001 | |||
| Resection margin status | R1 vs. R0 | 1.4 (1.3–1.5), P < 0.0001 | 1.2 (1.1–1.4), P < 0.0001 | ||
| Nodal stage | N+ vs. N0 | 1.5 (1.3–1.7), P < 0.0001 |
ANO7, anoctamin 7; cT, clinical tumor; pT, pathological tumor.