Figure 8.

The effects of BYSL or RIOK2 downregulation on glioma growth in vivo. An orthotopic xenograft model was established in nude mice. (A–D) Hematoxylin and eosin (H&E) staining was performed with whole brain sections from tumor-bearing mice. Representative H&E-stained images for the shRIOK2-2 and shBYSL groups are shown in A and C, respectively (100×). Graphs showed that silencing RIOK2 (B) or BYSL (D) significantly decreased the tumor volume. (E, F) Survival analysis showed that silencing RIOK2 or BYSL significantly prolonged the overall survival time of tumor-bearing mice. (G) A working model. BYSL and RIOK2 exist in the same complex with mTORC2, which is in turn connected to the AKT-mTORC1-P70S6K signaling, and thus increases ribosomal protein (e.g., S6) synthesis, leading to glioma cell growth and proliferation (*P < 0.05; **P < 0.01).