Figure 5.

Whole genome sequencing of P0 xenografts from 17 patient-derived xenograph models. (A) Single nucleotide variants (SNV), insertions (Ins) and deletions (Dels) mutations in the exon genome. The type of alteration is indicated by different colors, and bar length represents the number of SNV and Ins/Dels (i, ii). The mutation status (amino acid changes) is shown for a panel of genes that are currently of interest in routine practice for non-small cell lung cancers (iii). (B) Gene copy numbers are presented in a heat map, and variants indicated as gains (i.e., > 2) are shown by shades of green ( = 3), pink ( = 4), and red (> 5).