Table 3.
Genes, NATs, lncRNAs, and corresponding mice. List of mouse strains showing probable inadvertent partial/complete disruption of overlapping sequence of NATs on the antisense strand along with intended target genes
| Genes and gene ID | Function | NAT/lncRNA | Example of mouse strains | References |
|---|---|---|---|---|
| IL-1α (16175) | Regulatory role in immune response by promoting inflammation. | AS IL-1α | C57BL/6 J-Il1aem1(Luc-eGFP)Smoc mice | [14] |
| B6N(Cg)-Il1atm1b(EUCOMM)Wtsi/J (stock No.027517) | [46] | |||
| HoxD-3 (15434) | Transcription factor that plays a regulatory role in morphogenesis | Hoxd3os1 | Hoxd3−/− mice | [12] |
| Hoxa3−/−;hoxd3−/− mice | [13] | |||
| Igf2r (16004) | Receptor for insulin-like growth factor 2 and mannose 6-phosphate. Involved in intracellular lysosomal enzyme trafficking. | Airn | Igf2r mutant mice | [33] |
| Dlx-1 (13390) | Homeobox transcription factor involved in craniofacial patterning. | Dlx-1as | STOCK Dlx1/Dlx2tm1.1Rth/J (stock No. 025612) | [45] |
| Msx1 (17701) | Transcriptional repressor that plays a major regulatory role during early embryogenesis. | Msx1as | Msx1flox mice (stock No. 025204) | [17] |