TABLE 1.
Model inputs
| Parameter | Base‐case estimate male | Range for sensitivity analysis | Base‐case estimate female | Range for sensitivity analysis | Distribution | Sources |
|---|---|---|---|---|---|---|
| Baseline age | 40 | — | 40 | — | — | Assumption |
| All‐cause mortality | Life tables | — | Life tables | — | — | CDC Life Tables |
| Lifetime GC incidence (%) | 1.09 | — | 0.66 | — | β | SEER 2014–2016 1 |
| Annual probability of GC | 0.021 | (0.016–0.026) | 0.012 | (0.009–0.014) | β | SEER 2014–2016 1 |
| GC annual mortality, Ages <45 | 0.194 | (0.146–0.243) | 0.194 | (0.146–0.243) | β | SEER 2009–2015 1 |
| GC annual mortality, Ages 45–54 | 0.189 | (0.141–0.234) | 0.188 | (0.485–0.808) | β | SEER 2009–2015 1 |
| GC annual mortality, Ages 55–64 | 0.191 | (0.143–0.238) | 0.191 | (0.143–0.238) | β | SEER 2009–2015 1 |
| GC annual mortality, Ages 65–74 | 0.192 | (0.144–0.240) | 0.192 | (0.143–0.240) | β | SEER 2009–2015 1 |
| GC annual mortality, Ages 75+ | 0.249 | (0.187–0.311) | 0.249 | (0.187–0.311) | β | SEER 2009–2015 1 |
| Daily mean sodium intake (mg/d +/‐ SD) | 4090 +/‐ 1983 | — | 3073 +/‐ 1360 | — | — | NHANES 2016 19 |
| Daily mean sodium intake on DASH diet (mg/d +/‐ SD) | 1500 +/‐ 1000 | — | 1500 +/‐ 1000 | — | — | Clinical trial 14 |
| GC risk ratio of highest tertile of salt intake | 1.68 | (1.26–2.1) | 1.68 | (1.26–2.1) | Uniform | WCRF 2016, meta‐analysis 3 , 9 |
| GC risk ratio of intermediate tertile of salt intake | 1.41 | (1.06–1.76) | 1.41 | (1.06–1.76) | Uniform | WCRF 2016, meta‐analysis 3 , 9 |
| Cost GC, initial year, Ages <65 ($) | 111,682.24 | (55,841.12–223,364.48) | 101,180.00 | (50,590.00–202,360.00) | γ | National Cancer Institute 20 |
| Cost GC, initial year, Ages 65 ($) | 93,068.13 | (46,534.07–186,136.26) | 84,316.86 | (42,158.43–168,633.72) | γ | National Cancer Institute 20 |
| Cost GC, continuing care, Ages <65 ($/year) | 5079.70 | (2539.85–10,159.40) | 4717.88 | (2358.94–9435.76) | γ | National Cancer Institute 20 |
| Cost GC, final year, Ages <65 ($) | 190,631.13 | (95,315.57–381,262.26) | 184,629.68 | (92,314.84–369,259.36) | γ | National Cancer Institute 20 |
| Cost GC, final year, Ages 65 ($) | 127,087.42 | (63,543.71–254,174.84) | 123,087.24 | (61,543.62–246,174.48) | γ | National Cancer Institute 20 |
| Cost of low sodium‐DASH accordant diet ($/year) | 3299.60 | (1649.80–6599.20) | 2419.95 | (1209.98–4839.90) | γ | National Food Price Database 21 |
| Cost of intermediate accordant low sodium‐DASH diet ($/year) | 3014.90 | (1507.45–6029.80) | 2211.90 | (1105.95–4423.8) | γ | National Food Price Database 21 |
| Cost of least accordant low sodium‐DASH diet ($/year) | 2766.70 | (1383.35–5533.40) | 2029.40 | (1014.70–4058.80) | γ | National Food Price Database 21 |
| Utility healthy state | 1 | — | 1 | — | — | CEA registry 22 |
| Utility GC | 0.68 | 0.58–0.78 | 0.68 | 0.58–0.78 | β | CEA registry 22 |
| Utility low sodium‐DASH diet | 0.99 | 0.89–1.0 | 0.99 | 0.89–1.0 | β | Assumption |
| Adherence to diet (%) | 100 | 10–100 | 100 | 10–100 | β | Assumption |
Abbreviations: GC, gastric cancer; SD, standard deviation.