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. 2021 Jan 28;10:626751. doi: 10.3389/fonc.2020.626751

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Copyright © 2021 Borgenvik, Čančer, Hutter and Swartling

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug Targets in MYCN Biology. Proteins that can be targeted pharmacologically and discussed in the current review are marked in color. Drugs with preclinical data are denominated with group affiliation. A selected set of drugs that have reached the clinical stage (either approved or in clinical trials for the indicated target) are named. CDK1/2, Cyclin dependent kinase 1/2; MAX, MYC-associated factor X; MIZ1, MYC-interacting zinc-finger protein 1; RNA pol II, RNA polymerase II; BRD4, Bromodomain-containing protein 4; CYC T/K, Cyclin T/K; PROTACs, Proteolysis targeting chimeras; PI3K, Phosphoinositide 3-kinase; AURKB, Aurora kinase B; FBW7, F-box and WD repeat domain-containing 7; Ub, Ubiquitin; AURKA, Aurora kinase A; mTORC2, Mammalian target of rapamycin complex 2; mTORC1, Mammalian target of rapamycin complex 1; AKT, Protein kinase B; PP2A, Protein phosphatase 2; P, phosphorylation.