Table 4. Meta-analysis findings of the association between laboratory findings and COVID-19 ICU mortality.

Laboratory Finding	Number of studies	WMD (95% CI)	Meta-analysis P-value	Heterogeneity		Non-survived patients with data of the factor	Survived patients with data of the factor
				P-value	I2
Oxygenation
Pao2/FiO2, mm/Hg	2	-33.763 (-46.936 - -20.591)	<0.001	0.8	0	84	149
Cell Blood Count
Hemoglobin, g/dL	2	-0.380 (-1.348–0.587)	0.44	0.02	71.60	143	278
White blood cell count, x109 /L	2	4.280 (3.675–4.885)	<0.001	0.5	0	244	469
Lymphocyte count, x109 /L	3	-0.272 (-0.536 –-0.007)	0.044	<0.001	92.61	524	256
Platelet count/μl	3	-16.073 (-57.853–25.707)	0.45	<0.001	90.69	276	489
Coagulation index
D-dimer, ug/mL	3	6.685 (1.328–12.042)	0.014	<0.001	95.49	242	467
Prothrombin time, secs	3	1.646 (1.362–1.930)	<0.001	0.2	33.326	228	328
Inflammatory marker
CRP, mg/L	3	86.217 (47.912–124.523)	<0.001	<0.001	88.21	265	522
Biochemistry
Albumin, g/dL	2	-0.512 (-0.590 - -0.434)	<0.001	0.7	0	240	447
ALT, U/L	2	3.846 (-2.474–10.165)	0.233	0.12	59.17	189	426
AST, U/L	2	22.996 (11.696–34.296)	<0.001	0.01	84.59	239	447
Creatinine, mg/dL	3	0.325 (-0.044–0.695)	0.084	<0.001	96.44	279	492
Creatine kinase, U/L	2	378.166 (-127.086–883.418)	0.142	<0.001	95.73	175	284
Lactate, mmol/L	2	0.289 (0.027–0.551)	0.03	0.2	42.45	66	69
LDH, U/L	2	235.354 (174.931–295.778)	<0.001	0.01	84.63	200	399
Total bilirubin, mmol/L	2	5.317 (4.200–6.434)	<0.001	0.6	0	165	231

Abbreviation: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; LDH, lactate dehydrogenase; WMD, weighted mean difference.