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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Trends Immunol. 2021 Jan 11;42(2):104–119. doi: 10.1016/j.it.2020.12.001

Figure 2. Differentiation of circulating monocytes from bone marrow progenitor cells.

Figure 2.

Differentiation from early progenitors through progressively restricted ones that are then released into the circulation as classical monocytes (mice and humans) is regulated by the sequential expression of transcription factors (shown at the top). Alternative pathways to non-classical monocytes have also been proposed as indicated by the arrow. HSCs; hematopoietic stem cells, CMP; common myeloid progenitor cells, GMP; granulocytic myeloid progenitor cells, MDP; bipotent macrophage dendritic cell progenitor, cMoP; unipotent common monocyte progenitor.