. Author manuscript; available in PMC: 2022 Feb 1.

Published in final edited form as: Trends Immunol. 2021 Jan 11;42(2):104–119. doi: 10.1016/j.it.2020.12.001

Key Table, Table 1.

Classical and Non-Classical Monocytes in Humans and Mice

	“Classical” “Inflammatory”	“Non-Classical” “Patrolling”
Human surface antigen	CD14⁺⁺ CD16⁻ CCR2⁺ CSF1R	CD14⁺ CD16⁺ CSF1R
Mouse surface antigen	Ly6c⁺⁺ Treml4⁻ CCR2⁺ CSF1R	Ly6c⁻ Treml4⁺⁺ CSF1R
Recruitment	Recruited from blood through CCR2 release.	Migrate in response to CX3CL1
Transcription factors	PU1, JUN, FOS, IRF8, KLF4	PU1, NR4A1, KLF2
Genes up-regulated	VCAN, CD163, CD63 S100A12, S100A8,	FCGR3A, IFITM1–3, CDKN1C, MTSS1
Pathways up-regulated	Immune response, defense response, inflammatory response, chemotaxis, TLR, lysosome	Immune system process, leucocyte migration, cytoskeleton rearrangement
Metabolic profile	Carbohydrate Nucleotide production ROS production	Oxidative phosphorylation
Cytokines	TNFα, IL-1β, IL-6