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. 2020 Jul 31;14(1):222–230. doi: 10.1111/cts.12846

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© 2020 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Injury markers in perfusion fluid and morphological injury in tissue after normothermic machine perfusion. Total markers of injury were calculated as the area under the curve. Total amount of lactate dehydrogenase (LDH) (a, b) and aspartate aminotransferase (ASAT) (c, d) in the perfusate. Tissue was scored on proximal tubular cell necrosis (ranging from mild to severe: 1–5), edema (ranging from mild to severe: 1–4), and proximal tubular cell vacuolation (ranging from mild to severe: 1–4) in the rat study, respectively (e–g). Signs of ischemia reperfusion injury in porcine kidneys were scored (h). Data are presented as mean ± standard error of the mean. Groups contain 5–7 kidneys. *P < 0.05, **P < 0.01, compared with all other groups.