Table 1.

The DDGP and SMILE regimens

Agents	Dose	Route	Timing of treatment
DDGP
Pegaspargase	2,500 IU/m2	i.m.	Day 1
Gemcitabine	800 mg/m2	i.v.	Days 1 and 8
Cisplatin	20 mg/m2	i.v.	Days 1–4
Dexamethasone	15 mg/m2	i.v.	Days 1–5
SMILE
Methotrexate	2 g/m2	i.v. (6 hours)	Day 1
Dexamethasone	40 mg/m2	i.v.	Days 2–4
Ifosfamide	1,500 mg/m2	i.v.	Days 2–4
Mesna	300 mg/m2 × 3	i.v.	Days 2–4
Etoposide	100 mg/m2	i.v.	Days 2–4
L‐asparaginase	6,000 U/m2	i.v.	Days 3–9
or Pegaspargase	2,500 IU/m2	i.m.	Day 3

Cycles of DDGP and SMILE regimen were repeated every 21 days.

DDGP, cisplatin, dexamethasone, gemcitabine, and pegaspargase; SMILE, methotrexate, dexamethasone, ifosfamide, L‐asparaginase, and etoposide.