Table 4.
Adverse events between DDGP and SMILE groups
| Toxicity | Grade of adverse reaction | P value | |||||
|---|---|---|---|---|---|---|---|
| DDGP (N = 31) | SMILE (N = 23) | ||||||
| Grade | 0 | 1/2 | 3/4 | 0 | 1/2 | 3/4 | |
| Hematologic | |||||||
| Leukopenia | 1 | 12 | 18 | 0 | 3 | 20 | 0.021* |
| Neutropenia | 0 | 10 | 21 | 0 | 2 | 21 | 0.041* |
| Anemia | 3 | 12 | 16 | 1 | 10 | 12 | 0.829 |
| Thrombocytopenia | 2 | 11 | 18 | 2 | 6 | 15 | 0.677 |
| Nonhematologic | |||||||
| Hypofibrinogenemia | 13 | 17 | 1 | 12 | 9 | 2 | 0.637 |
| Prolonged APTT | 18 | 13 | 0 | 16 | 7 | 0 | 0.391 |
| Hyperbilirubinemia | 23 | 7 | 1 | 18 | 3 | 2 | 0.833 |
| ALT elevation | 12 | 19 | 0 | 11 | 7 | 5 | 0.771 |
| AST elevation | 14 | 17 | 0 | 12 | 6 | 5 | 0.734 |
| Creatinine | 29 | 2 | 0 | 20 | 3 | 0 | 0.413 |
| BUN | 29 | 2 | 0 | 20 | 3 | 0 | 0.413 |
| Nausea/vomiting | 0 | 23 | 8 | 0 | 18 | 5 | 0.732 |
| Mucositis | 31 | 0 | 0 | 21 | 2 | 0 | 0.097 |
| Allergy | 31 | 0 | 0 | 20 | 2 | 1 | 0.040* |
ALT, alanine aminotransferase; APTT, activated partial thromboplastin time; AST, aspartate aminotransferase; BUN, blood urea nitrogen; DDGP, cisplatin, dexamethasone, gemcitabine, and pegaspargase; SMILE, methotrexate, dexamethasone, ifosfamide, L‐asparaginase, and etoposide.
*
P < 0.05.