Table 1.
Summary of pharmacokinetic variables of cenerimod administered at a single oral dose of 4 mg in white and Asian subjects (n = 8 per ethnicity)
| Cmax, ng/mL | AUC0–t, hour·ng/mL | AUC0–∞, hour·ng/mL | Tmax, hour | t1/2, hour | |
|---|---|---|---|---|---|
| Asian, N = 8a | 20.1 (16.2–24.8) | 3,216 (2,470–4,186) | 3,422 (2,613–4,482) | 6.00 (6.00–8.08) | 299 (244–366) |
| White, N = 8a | 20.4 (17.0–24.4) | 3,357 (2,720–4,143) | 3,548 (2,910–4,327) | 8.00 (6.00–8.05) | 288 (250–332) |
| Ratio of geometric means (90% CI) Asian/whiteb | 0.99 (0.80–1.21) | 0.96 (0.75–1.23) | 0.96 (0.75–1.24) | 1.04 (0.86–1.25) | |
| Median (range) Asian/whiteb | –1.00 (−2.00–0.00) |
AUC0‐∞, area under the plasma concentration‐time curve from zero to infinity; AUC0–t, area under the plasma concentration‐time curve from zero to time of the last measured concentration above the limit of quantification; CI, confidence interval; Cmax, maximum plasma concentration; t1/2, terminal half‐life; Tmax, time to reach maximum plasma concentration.
a
Data are presented as geometric mean (95% CI) except for Tmax: median (range).
b
Data are presented as geometric mean ratios (90% CI) except for Tmax: median (range).