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Impact of fractionated ADC dosing on receptor occupancy. (a, b) Simulated percent receptor occupancy across time and a theoretical tumor over 1 month is given for ADC dosing fractionated at (a) 10 mg QW or (b) 40 mg Q4W. RO radially across the tumor at day 1 (solid line) and day 21 (dashed line) are given for the (c) QW and (d) Q4W dose schedules.
