Table 3.
Radiolabeling and PET imaging application of FAAH specific tracers
| Radioligand (RCYs) | PET imaging study |
|
|---|---|---|
| subject | brain uptake | |
| [11C]36 (4%a) | Rodents, Human: cannabis addiction, alcohol use disorders, psychiatric, borderline personality disorder | Rat: SUVmax = 2±0.4 Human: SUVmax = 4.3±0.8 (putamen) |
| [11C]43 (20±4.6%b) | Rodents, NHP | Rat: SUVmax ~ 1.5 (cerebellar nucleus) Monkey: SUVmax = 2.0 (occipital cortex) |
| [11C]44 (19.5±2.5%b) | Rodents, NHP | Rat: SUVmax = 4.55±0.57 (cortex) Baboon: SUVmax=2.1 (whole brain,55 min) |
| [11C]45 (15±5%b) | Rodents | Rat: SUVmax = 7.8±0.1 (cortex,40 min) |
| [11C]46 (4.5±1.3%) | Rodents | Rat: SUVmax = 2.8±1.6 |
| [11C]47 (10.7±4.4%b) | Rodents | SUV ~ 0.8 (cortex, 90 min) |
| [11C]50 (-) | NHP, Human | Monkey: BP: 0.7±0.3, VT: 3.5±0.5 Monkey: SUVmax >1 Human: VT: 17±3 |
| [18F]51 (13%a) | Rodents | Mice: SUVmax =0.87 (cerebellar nuclei, 1.5 min) |
| [18F]52 (17±6%b) | Rodents | 9.2 %ID/g |
a
non-decay corrected RCYs
b
decay corrected RCYs
The data of PET imaging are listed only in the control group.