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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Curr Opin HIV AIDS. 2020 Sep;15(5):267–274. doi: 10.1097/COH.0000000000000639

Figure 2.

Figure 2

Pros and cons of immunogens with varying glycan shields.

Left: An Env with a glycan hole at N276 is shown, similar to CD4bs germline targeting immunogens. Middle: An Env with complete glycan shield is shown. Right: An Env with all conserved glycans, but grown in GnTI knockout cell-lines is shown. The pros and cons for each immunogen type are listed based on discussion in the text. Glycans were modeled on BG505 trimer structure PDB: 5FYL [1] using GlyProt (www.glycosciences.de) with default oligomannose or complex glycans, or Man5 for GnTI-. Missing glycans in BG505 at sites 130, 241 and 289 were artificially introduced. For left and middle panels, information from Cao et al. [17**] was used on whether a site is predominantly oligomannose or complex. For the right panel, all complex glycans in the middle panel were replaced by Man5 to approximate GnTI- activity.

Original