Table 1. Assignment of novel positively or negatively selected cancer genes to key cellular processes of carcinogenesis.

Hallmarks of cancer	Gene symbol
Defects of genome, epigenome, transcriptome, or proteome maintenance	CDK8, FOXG1, IDH3B, MARCH7, MGA, NOVA1, PNCK, RNF128, TGIF1, TNRC6B, TWIST1, ZC3H13, ZFP36L1, ZFP36L2, ZNF750
Sustained proliferation	AURKA, BRD7, ING1, FOXG1, MAPK13, PNCK, PRRT2, RASA1, RIT1, SPRED1, TRIB2, TTK, YAP1, YES1, ZFP36L1, ZFP36L2, ZNF750
Evasion of growth suppressors
Reprogramming of metabolism	BRD7, G6PD, SLC16A1, SLC16A3, SLC2A1, SLC2A8, YAP1, YES1
Replicative immortality	NOVA1
Evasion of cell death	BRD7, ING1, MAPK13, PNCK, PRRT2, TP73, TRIB2, TTK, YAP1, YES1, ZNF750
Evasion of immune destruction
Tumor promoting inflammation	BMP2R, CCR2, CCR5, CX3CR1, MAPK13
Inducing angiogenesis	CCR2
Activation of invasion and metastasis	CCR2, CCR5, CX3CR1, RASA1, TBXA2R

For annotation of novel genes identified in the present study see Appendix 1. The names of negatively selected genes are marked by bold underline.