Table 3.
Prognostic utility of H-FABP in patients with ACS.
| First Author, Year | N | Population (Time of blood sampling) | Follow up | Primary outcome | Biomarkers | Findings |
|---|---|---|---|---|---|---|
| Ishii, 2005 [66] | 328 | ACS (<6-h after s/s onset) | 6-mo | Cardiac death Cardiac events |
H-FABP c-Tn |
H-FABP predicted 6-month cardiac events (RR 8.92, 1.15–69.4) but not cTn. |
| Suzuki, 2005 [67] | 90 | ACS (Admission) | 30-d | All-cause death Cardiac event |
H-FABP Troponin T CK-MB |
HFABP predicted cardiac events at 30-days (RR 44.98, 1.48–1364.88) but not cTn or CK-MB |
| O'Donoghue, 2006 [68] | 2,287 | ACS (41 ± 20 h after s/s onset) |
10-mo | All-cause death Nonfatal AMI New/worsening CHF |
H-FABP cTn BNP Myoglobin |
H-FABP predicteddeath (HR 4.1, 2.6–6.5), CHF (HR 4.5, 2.6–7.8), MI (HR 1.6, 1.0–2.5), or all (HR 2.6, 1.9–3.5)10 months independent of cTn/BNP. H-FABP incremental to cTn/BNP for prognosis. |
| Kilcullen, 2007 [69] | 1,448 | ACS (12-24 h after s/s) | 12-mo | All-cause death | H-FABP cTn |
H-FABP ≥ 5.8 ng/ml predicted 1-yr mortality (HR 11.35, 2–64.34) in cTn-negative (UA) patients, as well in those with ↑ cTn (NSTEMI) (HR 3.11, 1.45–6.7). |
| Ilva, 2009 [70] | 293 | Suspected ACS (Median 4.7 h after s/s onset) | 6-mo | All-cause death Recurrent MI |
cTnI H-FABP |
cTnI independently predicted 6-mo death + AMI (RR 3.02, 1.62–5.63) but not H-FABP. |
| McCann, 2009 [71] | 550 | Suspected ACS (Median 6 h after s/s onset) | 12-mo | All-cause death Recurrent AMI |
H-FABP cTn NT-pro-BNP hs-CRP MPO MMP-9 others |
AmissionH-FABP(OR 2.7, 1.1–6.4), admission NT-pro-BNP (OR 2.7, 1.4-5.2), and peak cTn(OR 3.6, 1.4–9.0)independently predicted 1-yr mortality. |
| H-FABP, cTn, NT-pro-BNP had incremental prognostic value | ||||||
| Viswanathan, 2010 [72] | 955 | hs-Tn-negative suspected ACS (NR) | 18-mo | All-cause death Recurrent AMI |
H-FABP hs-Tn |
H-FABP predicted 18-month death/MI in hs-Tn (-) patients incrementally when stratified by degree of H-FABP elevation. |
| Garcia-Valdecasas, 2011 [26] | 165 | Chest pain (<6 h after s/s onset) | 6-mo | All-cause death Recurrent ACS/AMI Other cardiac events |
cTnI H-FABP CK-MB |
Increased H-FABP (HR 2.50, 1.31–4.80) and cTnI(2.53, 1.19–5.38) independently predicted 6 month outcomes. |
| Reiter, 2013 [58] | 955 | Chest pain suggestive of MI (<12-h after onset/peak of symptoms) | 12-mo | All-cause death | H-FABP Copeptin hs-Tn |
H-FABP predicted 1-yr mortalityirrespective of hs-Tn |