Table 3.
Risk discrimination and reclassification upon addition of normalized handgrip strength to the DESIR T2D risk prediction model containing conventional risk factors.
| Discrimination | Overall | Men | Women |
|---|---|---|---|
| C-index (95% CI): conventional risk factors | 0.6596 (0.5904 to0.7288) | 0.5508 (0.4303 to 0.6713) | 0.7441 (0.6697 to 0.8185) |
| C-index (95% CI): conventional risk factors plus HGS | 0.6979 (0.6261 to 0.7698) | 0.6326 (0.5284 to 0.7368) | 0.7588 (0.6804 to 0.8371) |
| C-index change (95% CI) | 0.0383 (–0.0047 to 0.0814) | 0.08181 (–0.0429 to 0.2065) | 0.0147 (–0.0167 to 0.0460) |
| p-value | .08 | .20 | .36 |
| p-value for difference in −2 log likelihood | .01 | .25 | .03 |
| Reclassification | |||
| Continuous Net reclassification index (95% CI) | 33.26% (–18.09 to 84.60) | 55.20% (–44.08 to 154.49) | 15.09% (–49.11 to 79.29) |
| p-value | .20 | .28 | .65 |
| Integrated discrimination index (95% CI) | 0.0122 (0.0002 to 0.0242) | 0.0075 (–0.008 to 0.0178) | 0.0160 (–0.0001 to 0.0321) |
| p-value | .05 | .16 | .05 |
DESIR: Data from the Epidemiological Study on the Insulin Resistance Syndrome; HGS: handgrip strength; T2D: type 2 diabetes. The model with conventional risk factors included sex, smoking, parental history of diabetes, hypertension and waist circumference (smoking, hypertension and waist circumference for men and parental history of diabetes, hypertension and waist circumference for women).