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Schematic mechanism of Mox ameliorates POF through inhibiting NLRP3-/caspase-1-/GSDMD-dependent pyroptosis. Mox directly inhibited TXNIP/NLRP3/caspase-1 signaling-induced pyroptosis. Meanwhile, Mox indirectly decreased NLRP3, pro-IL-1β, and pro-IL-18 through inhibiting TLR4/MyD88/NF-κB signaling. Our results show that inhibiting pyroptosis or giving Mox might be a new treatment for POF.
