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. 2021 Feb 10;9(1):e001492. doi: 10.1136/bmjdrc-2020-001492

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Changes in expression of fractalkine, CX3CR1, IGF-1 and BDNF in the brain of DIO mice. (A) Fractalkine mRNA expression, (B) fractalkine protein levels, (C) CX3CR1 mRNA expression, (D) CX3CR1 protein levels, (E) IGF-1 protein levels, and (F) BDNF protein levels in the hippocampus. (G) Fractalkine and CX3CR1 mRNA expression in the amygdala. (H) Fractalkine and CX3CR1 mRNA expression in the PFC. Results are expressed as mean±SE for 5–16 mice. *P<0.05, **P<0.01 versus CD. BDNF, brain-derived neurotrophic factor; CD, control diet; CX3CR1, CX3C chemokine receptor 1; DIO, diet-induced obese; IGF-1, insulin-like growth factor-1; mRNA, messenger RNA; PFC, prefrontal cortex.