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. 2021 Feb 10;9(1):e001492. doi: 10.1136/bmjdrc-2020-001492

Figure 3.

Figure 3

Cognitive ability in the Y-maze test and changes in mRNA expression and protein levels of NMDA and AMPA receptor subunits, synaptophysin and PSD-95 in the hippocampus in DIO mice. Y-maze test: (A) spontaneous alternation (%) and (B) number of arm entries. NR1: (C) mRNA expression and (D) protein levels. NR2A: (E) mRNA expression and (F) protein levels. NR2B: (G) mRNA expression and (H) protein levels. GluR1: (I) mRNA expression and (J) protein levels. GluR2: (K) mRNA expression and (L) protein levels. Synaptophysin: (M) mRNA expression and (N) protein levels. PSD-95: (O) mRNA expression and (P) protein levels. Results are expressed as mean±SE for 5–18 mice. *P<0.05, **P<0.01 versus CD. AMPA, α-amino-5-methyl-3-hydroxy-4-isoxazole propionate; CD, control diet; DIO, diet-induced obese; mRNA, messenger RNA; NMDA, N-methyl-D-aspartate; PSD-95, postsynaptic density protein 95.