Extended Data Fig. 6: Simulation of optoelectronic-induced temperature change in silico.

a, Elements and their relative 3D geometry used to model the appropriate heat transfer. The micro-LED array is placed epineurally, distributing equally 4 micro-LEDs or heat sources on the sciatic nerve. b, Thermodynamic parameters of the elements used in the thermal model. c, Temperature changes predicted by the 3D model, presented in cross and longitudinal sections. For visualization, the simulated photostimulation parameters (100 mW/mm², 10% activation duty cycle) exceed the ones used in the in vivo experiments. d, Distribution of optoelectronic-induced temperature change across the different elements as a function of photostimulation irradiance. e, Maximum temperature increment at the interface between inner nerve and epineurium as a function of irradiance and micro-LED activation duty cycle.