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Dichotomous expression of mouse IPAN markers compared to human ENS.
(A) In human ileum sections CALB1+ (type III neuron marker) co-localizes with KLHL1 (arrowheads). Contrasting with mouse, NXPH2 rarely localized with KLHL1 or CALB1 (arrow).
(B) Co-expression of CALB1, KLHL1, and NXPH2 marks a distinct human EN subtype in colon.
(C) Summary of the cross-species comparisons for subtypes of ENs examined here.
