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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Gastroenterology. 2020 Nov 2;160(3):863–874. doi: 10.1053/j.gastro.2020.10.042

Figure 7. The cGAS/STING pathway plays a critical role in the ability of mEVs to trigger inflammatory responses.

Figure 7.

(A-C) The levels of cGAS and STING phosphorylation in the liver, skeletal muscle, and epididymal fat of NCD CRIgKO recipient mice after 4 weeks treatment of obese mEVs. (D and E) Effects of obese mEVs on the activation of cGAS/STING pathway in hepatocytes and adipocytes. (F and G) The influence of cGAS ablation on the responses of adipocytes and hepatocytes to obese mEV treatment. (H and I) Glucose tolerance and insulin sensitivity of 8wks HFD cGASKO mice after 4wks treatment with obese mEVs. Data are presented as mean ± SEM. n=6 per group (F and G); n=5 per group (H and I) *P<0.05, **P<0.01, Student’s t test.