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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Gastroenterology. 2020 Oct 29;160(3):781–796. doi: 10.1053/j.gastro.2020.10.036

Figure 6. PD-L1-overexpressing myeloid cells facilitate gastric tumorigenesis.

Figure 6.

(A-B) Gross images (A) and tumor area measured (B) from R26-PD-L1 and LysM-Cre; R26-PD-L1 mice at 36 weeks post-MNU +/− Hf (n = 5-12/group). Dotted lines indicate tumor area. Scale bars, 5 mm (A).

(C-D) The percentage of tumor-infiltrating MDSCs and T cells (n = 4-9/group).

(E-F) The percentage of Ki-67+ (E), effector cytokine-positive cells (F) in CD8+ T cells isolated from MNU-induced R26-PD-L1 and LysM-Cre; R26-PD-L1 tumors (n = 3/group).

Mean ± SEM. one-way ANOVA (B); Student’s t-test (C-F). *P < .05; **P < .01; ***P < .001; n.s., not significant.