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. 2021 Jan 29;11:617836. doi: 10.3389/fphar.2020.617836

Figure 8.

Figure 8

Effects of integrin antagonists on IL-1β expression in ARPE-19-Jurkat cells after 24 h of co-culture with Jurkat cells. IL-1β expression, significantly increased in both ARPE-19 (A) and Jurkat cells (B) after 24 h of co-culture, was significantly reduced by integrin antagonists MN27, SR714 and DS-70 in both ARPE-19 and Jurkat cells. PD 98059 (10 μM), an ERK1/2 signaling inhibitor pre-incubated with the cells 30 min before starting the co-culture, prevented IL-1β expression increment both in ARPE-19 and Jurkat cells. Data are expressed as mean ± SD of four independent experiments. ***p < 0.001 versus ARPE-19/Jurkat; #p < 0.05; ##p < 0.01; ###p < 0.001 vs ARPE-19 + Jurkat 24 h/Jurkat 24 h (Newman−Keuls test after ANOVA).