Table 3.

Similarities between the two IgG4-AID-associated HLA variants DRB1*0404 and DRB1*0102 in the protein sequence of the two HLA variants (a) and in the amino acid motifs of the peptides bound by these two HLA variants (b).

a) Residues characterizing the binding pockets of DRB1*0404 and DRB1*0102
DRB1*	P1	P4	P6	P7	P9
0404	V	H Q R A Y	V	D Y Y L R	E Y D Y
0102	V	F Q R A Y	L	E C Y L R	W S D Y
b) Amino acid motifs of peptides bound to pockets of DRB1*0404 and DRB1*0102
DRB1*	P1	P4	P6	P7	P9
0404	VLMIF	ALIV/WDEFY/no KR	STNQR	ADHIL/MNPST	ALV/QGSTK
0102	VLMIF	ALIV/MNQ/no HKR	AGSTP		ALV/INFY

Table adapted from (25). Negative charged amino acid (D, E) are in bold, positively charged amino acids (R) are underlined. P1-P9: binding pockets.