Table 2.
Top pathways in sperm cells that were significantly enriched with genes (n=912) altered by exposure to iAsa
| Category | Pathway | Fold enrichment | p-value | Benjamini Hochberg adjusted p-value |
|---|---|---|---|---|
| KEGG | Focal adhesion | 3.25 | 9.71E-08 | 2.43E-05 |
| KEGG | PI3K-Akt signaling pathway | 2.53 | 3.57E-07 | 4.46E-05 |
| KEGG | ECM-receptor interaction | 3.82 | 6.08E-05 | 0.005 |
| Gene Ontology | Collagen trimer | 4.05 | 3.59E-05 | 0.001 |
| Gene Ontology | Insulin-like growth factor binding | 8.35 | 2.84E-05 | 0.006 |
| Gene Ontology | Positive regulation of non-canonical Wnt signaling | 19.54 | 4.57E-05 | 0.024 |
a
Differentially expressed genes (p<0.05) were analyzed for pathways enrichment; the significantly enriched pathways were identified using a Benjamini-Hochberg adjusted p-value <0.1.