Table 4.

Top pathways in livers of male offspring that were significantly enriched among genes (n=843) altered by preconception exposure to iAs^a

Category	Pathway	Fold enrichment	p-value	Benjamini Hochberg adjusted p-value
KEGG	Focal adhesion	2.69	9.71E-06	0.001
KEGG	ECM-receptor interaction	3.41	1.90E-04	0.006
KEGG	PI3K-Akt signaling pathway	1.89	8.38E-04	0.023
Gene ontology	Cell cycle	1.98	8.46E-06	0.006
Gene ontology	Platelet-derived growth factor binding	12.32	6.73E-05	0.011
Gene ontology	Extracellular matrix structural constituent	5.40	2.04E-04	0.017
KEGG	Protein digestion and absorption	2.92	0.002381	0.049
Gene ontology	Collagen trimer	3.052	0.005332	0.079
Gene ontology	Leukocyte cell-cell adhesion	8.29	3.11E-05	0.014
Gene ontology	Membrane to membrane docking	19.89	6.07E-04	0.086
Gene ontology	ATP binding	1.45	2.92E-04	0.023
Gene ontology	Nucleotide binding	1.38	3.37E-04	0.024
Gene ontology	Cadherin binding involved in cell-cell adhesion	2.20	4.45E-04	0.027
Gene ontology	Cell-cell adherens junction	2.00	0.00175	0.031
Gene ontology	MCM complex	14.07	2.58E-04	0.007
Gene ontology	DNA unwinding involved in DNA replication	12.43	4.46E-04	0.070
KEGG	DNA replication	4.29	0.004963	0.086
Gene ontology	Chromosome condensation	9.32	3.11E-04	0.061
Gene ontology	Membrane to membrane docking	19.89	6.07E-04	0.086
KEGG	Bladder cancer	5.23	8.46E-05	0.005
Gene ontology	Phosphatidylinositol-3,4-bisphosphate binding	6.72	0.001597	0.071
Gene ontology	GO:0030261~chromosome condensation	9.32	3.11E-04	0.061

^aDifferentially expressed genes (p<0.05) were analyzed for pathways enrichment; the significantly enriched pathways were identified using a Benjamini-Hochberg adjusted p-value <0.1.