Table 5.
Top pathways in livers of female offspring that were significantly enriched among genes (n=1407) altered by preconception exposure to iAsa
| Category | Pathway | Fold enrichment | P-value | Benjamini Hochberg adjusted p-value |
|---|---|---|---|---|
| Gene Ontology | Ribosome | 4.55 | 4.07E-21 | 1.34E-18 |
| KEGG | Ribosome | 4.66 | 5.97E-20 | 1.57E-17 |
| Gene Ontology | Intracellular ribonucleoprotein complex | 3.27 | 1.84E-17 | 3.02E-15 |
| Gene Ontology | Structural constituent of ribosome | 3.42 | 4.95E-16 | 5.21E-13 |
| Gene Ontology | Translation | 2.36 | 6.75E-10 | 2.36E-06 |
| Gene Ontology | Cytosolic large ribosomal subunit | 3.83 | 1.64E-07 | 8.29E-06 |
| Gene Ontology | Mitochondrial inner membrane | 3.19 | 6.91E-20 | 1.51E-17 |
| Gene Ontology | Respiratory chain | 6.28 | 2.03E-12 | 1.67E-10 |
| KEGG | Oxidative phosphorylation | 3.74 | 3.56E-12 | 4.68E-10 |
| Gene Ontology | Mitochondrial respiratory chain complex I | 6.74 | 1.73E-11 | 1.26E-09 |
| KEGG | Parkinson’s disease | 3.40 | 1.40E-10 | 1.23E-08 |
| KEGG | Huntington’s disease | 2.84 | 3.10E-09 | 1.63E-07 |
| KEGG | Non-alcoholic fatty liver disease (NAFLD) | 2.87 | 1.27E-07 | 5.55E-06 |
| KEGG | Alzheimer’s disease | 2.70 | 2.06E-07 | 7.73E-06 |
| Gene Ontology | NADH dehydrogenase (ubiquinone) activity | 4.98 | 4.07E-05 | 0.007 |
| Gene Ontology | NADH dehydrogenase activity | 8.54 | 7.20E-05 | 0.011 |
| Gene Ontology | Cytosolic small ribosomal subunit | 4.78 | 5.81E-07 | 2.72E-05 |
| Gene Ontology | Ribosomal small subunit assembly | 7.41 | 2.59E-06 | 0.003 |
| Gene Ontology | Small ribosomal subunit | 4.92 | 3.17E-04 | 0.009 |
| Gene Ontology | Peroxisome | 3.02 | 2.03E-06 | 8.90E-05 |
| KEGG | Peroxisome | 3.39 | 3.72E-06 | 1.22E-04 |
| Gene Ontology | Peroxisomal membrane | 3.29 | 0.001 | 0.038 |
| KEGG | Valine, leucine and isoleucine degradation | 3.07 | 0.001 | 0.040 |
| Gene Ontology | Proteasome complex | 3.12 | 7.69E-04 | 0.020 |
| Gene Ontology | Sex chromatin | 10.57 | 0.004 | 0.087 |
a
Differentially expressed genes (p<0.05) were analyzed for pathways enrichment; the significantly enriched pathways were identified using a Benjamini-Hochberg adjusted p-value <0.1.