Table 6.
The pathways that were significantly enriched among genes (n=95) altered by preconception exposure to iAs in both the parental sperm and the liver of male offspring a
| Category | Pathway | Fold enrichment | p-value | Benjamini Hochberg adjusted p-value |
|---|---|---|---|---|
| Gene Ontology | extracellular matrix | 16.16 | 1.47E-19 | 2.26E-17 |
| Gene Ontology | proteinaceous extracellular matrix | 15.04 | 6.50E-19 | 5.00E-17 |
| Gene Ontology | extracellular region | 3.82 | 8.42E-11 | 4.32E-09 |
| Gene ontology | extracellular space | 3.44 | 1.90E-07 | 4.87E-06 |
| Gene ontology | collagen trimer | 20.82 | 1.04E-07 | 3.20E-06 |
| Gene ontology | platelet-derived growth factor binding | 90.86 | 1.88E-07 | 3.77E-05 |
| Gene Ontology | extracellular matrix structural constituent | 31.91 | 1.10E-06 | 1.11E-04 |
| KEGG | ECM-receptor interaction | 16.53 | 2.79E-06 | 2.71E-04 |
| KEGG | Protein digestion and absorption | 16.53 | 2.79E-06 | 2.71E-04 |
| KEGG | PI3K-Akt signaling pathway | 6.51 | 3.03E-06 | 1.47E-04 |
| KEGG | Focal adhesion | 9.03 | 3.81E-06 | 1.23E-04 |
| Gene Ontology | collagen fibril organization | 27.27 | 3.15E-05 | 0.010914 |
| Gene Ontology | cellular response to amino acid stimulus | 10.86 | 4.24E-05 | 0.00981 |
| Gene Ontology | protein heterotrimerization | 44.78 | 8.88E-05 | 0.012305 |
| Gene Ontology | wound healing | 15.84 | 4.93E-06 | 0.003428 |
| Gene Ontology | cellular response to amino acid stimulus | 10.86 | 4.24E-05 | 0.00981 |
a
Genes (p<0.05) were analyzed for pathways enrichment; the significantly enriched pathways were identified using a Benjamini-Hochberg adjusted p-value <0.1.