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. Author manuscript; available in PMC: 2022 Feb 10.
Published in final edited form as: Cell Host Microbe. 2020 Dec 18;29(2):165–178.e8. doi: 10.1016/j.chom.2020.11.013

Figure 1. Study outline of rhesus macaques with LTBI and PTB.

Figure 1.

A. Single cell suspensions of lung biopsy from uninfected rhesus macaques (control), macaques with PTB at terminal end-point, or LTBI at 6 months were subjected to scRNA-seq or CyTOF analysis as described in STAR methods.

B. Clinical correlates of infection including changes in the percentage of body weight, changes in serum CRP (mg/dL) levels, and post-necropsy percent of lung pathology in Mtb-infected LTBI and PTB macaques. Data represented as mean ± SD, **p < 0.01, unpaired Student’s T-test.

C-D. UMAP plots of cells from all scRNA-seq samples together, colored according to (C) lymphoid/myeloid classification or (D) cell types. Control, n=3; PTB, n=5; LTBI, n=2.

E. Proportion of each cell type across samples.

F. UMAP plots with the expression of markers, characterizing main immune populations. See also Fig S1, Table S1 and Table S2.