Table 1.
N of patients | Age mean (range) [years] | Sex | ICU stay mean (range) [days] | Medication | Clinical feature | NCS/EMG | Muscle biopsy | CK peak-level | IL-6 peak-level | |
---|---|---|---|---|---|---|---|---|---|---|
(9) | 7 | NA | NA | NA | Antiretrovirals, neuromuscular blockers, corticosteroids, antibiotics | Generalized muscular weakness | Myopathy | Three patients (scattered necrotic and regenerative fibers, no inflammatory infiltrates) | 181–3,228 μmol/l | N/A |
(10) | 5 | N/A | N/A | N/A | Antirheumatics, antiretrovirals, corticosteroids, antibiotics | Generalized muscular weakness | Myopathy | ND | 61–1,206 μg/l | NA |
(8) | 6 | 61 (51-72) | 1 F | 6-14 until NCS/EMG | Antirheumatics, antiretrovirals, corticosteroids, antibiotics, anticoagulants | Acute flaccid quadriplegia | Myopathy; reduced CMAP amplitude with markedly prolonged duration | ND | 55–1,274 UI/L | 18.4–5,402.2 ng/ml |
(6) | 1 | 68 | M | 65 | Antibiotics | Severe symmetrical proximal and distal weakness and diffuse muscle wasting | Myopathy and bilateral peroneal compression neuropathy. | ND | NA | NA |
(7) | 1 | 62 | F | 30 | Antirheumatics, antiretrovirals, antibiotics, neuromuscular blockers, antifungal drugs, corticosteroids. | Symmetrical muscle weakness predominant in lower limbs and proximal muscles. | Myopathy | ND | Normal | NA |
ICU, intensive care unit; NCS/EMG, nerve conduction studies/electromyography; CK, creatine kinase; IL-6, interleukine 6; F, female; M, male; CMAP, compound muscle action potential; ND not done; NA not available.