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. 2021 Jan 29;12:625144. doi: 10.3389/fneur.2021.625144

Table 1.

Studies on COVID-19-patients with intensive care unit acquired myopathy.

N of patients Age mean (range) [years] Sex ICU stay mean (range) [days] Medication Clinical feature NCS/EMG Muscle biopsy CK peak-level IL-6 peak-level
(9) 7 NA NA NA Antiretrovirals, neuromuscular blockers, corticosteroids, antibiotics Generalized muscular weakness Myopathy Three patients (scattered necrotic and regenerative fibers, no inflammatory infiltrates) 181–3,228 μmol/l N/A
(10) 5 N/A N/A N/A Antirheumatics, antiretrovirals, corticosteroids, antibiotics Generalized muscular weakness Myopathy ND 61–1,206 μg/l NA
(8) 6 61 (51-72) 1 F 6-14 until NCS/EMG Antirheumatics, antiretrovirals, corticosteroids, antibiotics, anticoagulants Acute flaccid quadriplegia Myopathy; reduced CMAP amplitude with markedly prolonged duration ND 55–1,274 UI/L 18.4–5,402.2 ng/ml
(6) 1 68 M 65 Antibiotics Severe symmetrical proximal and distal weakness and diffuse muscle wasting Myopathy and bilateral peroneal compression neuropathy. ND NA NA
(7) 1 62 F 30 Antirheumatics, antiretrovirals, antibiotics, neuromuscular blockers, antifungal drugs, corticosteroids. Symmetrical muscle weakness predominant in lower limbs and proximal muscles. Myopathy ND Normal NA

ICU, intensive care unit; NCS/EMG, nerve conduction studies/electromyography; CK, creatine kinase; IL-6, interleukine 6; F, female; M, male; CMAP, compound muscle action potential; ND not done; NA not available.