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. 2021 Jan 29;12:625144. doi: 10.3389/fneur.2021.625144

Table 2.

Demographic, clinical, laboratory, and electrodiagnostic data.

Patient Age Sex ICU stay Clinical features Laboratory findings (peak levels) NCS/EMG: time since disease onset Sensory NCS Motor NCS EMG
CK CRP IL-6 D-dimer WBC Lymphocyte SNAP amplitude sNCV CMAP amplitude CMAP duration DML mNCV Proximal muscles*
[weeks] [U/l] [mg/l] [pg/ml] [mg/l] [×103/μl] [×103/μl] [weeks] [μV] [m/s] [mV] [ms] [ms] [m/s]
40–220 <0.8 <7.0 <0.5 3.6–10.5 1.1–4.5
1 77 M 6 Proximal weakness and muscle wasting in upper more than lower limbs; myalgia; fatigue 4,002 15.9 225.2 1.5 10.1 2.8 7 L median: 15.2 50 L median: 4.2 9.3 3.9 48 Myopathic
R ulnar: 12.4 48 R ulnar: 5.7 13.7 2.9 55
R sural: 6.3 47 L peroneal: 2.1 7.3 3.1 40
R tibial: 2.4 4.2 4.0 41
2 58 M 3 Predominantly proximal weakness in four limbs; hyporeflexia; myalgia 6,732 17.1 343.6 2.1 9.9 4.6 4 L median: 22.5 49 L median: 3.9 9.0 3.8 48 Myopathic
R ulnar: 25.8 51 R ulnar: 4.8 8.7 2.5 50
R sural: 9.5 48 L peroneal: 1.2 6.5 4.0 39
R tibial: 2.2 6.7 4.1 40

Laboratory data were obtained during intensive care. Clinical and electrodiagnostic data were obtained during neurorehabilitation.

M, male; F, female; ICU, intensive care unit; CK, creatine kinase; CRP, C-reactive protein; WBC, white blood cell count; IL, interleukin; NCS, nerve conduction study; EMG, electromyography; SNAP, sensory nerve action potential; sNCV, sensory nerve conduction velocity; CMAP, compound muscle action potential; DML, distal motor latency; mNCV, motor nerve conduction velocity; R, right; L, left.

The upper limits of normality (mean + 2 SD) for distal CMAP duration using a low frequency filter of 2 Hz are: median nerve = 7.3 ms, ulnar nerve = 7.5 ms, peroneal nerve = 7.3 ms, tibial nerve = 6.8 ms (12); abnormal values are marked in bold.

*

Left deltoid, right triceps brachii, left iliopsoas, and right rectus femoris muscles.